I found out only recently that most familiar Firefox settings are accessible via about:config.
I already changed a few cookie-related.
Not as good as uMatrix etc. but it's a start.
Javascript still worries me though. On an outdated mozilla engine. It can be disabled completely, but if it can't be enabled easily that's not practical.

I will tackle hosts-based ad-blocking soon. I use system-wide domain blocking on all my computers and wouldn't want to miss it anymore.